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- In addition to this diffuse large B-cell lymphoma is the most commonly seen subtype of NHL in both species.
- Children with non-Hodgkin's lymphoma (NHL), specifically with Burkitt's lymphoma and B-cell acute lymphoblastic leukemia (B-ALL), often experience tumor lysis syndrome (TLS), which occurs when breakdown of tumor cells by chemotherapy releases uric acid and cause the formation of uric acid crystals in the renal tubules and collecting ducts.
- The experimental drug, developed by ADC Therapeutics is being tested in clinical trials for the treatment of B-cell Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma (NHL), and for the treatment of B-cell acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
- Reports in 2013, showed interim results from a Phase II, open-label, single-arm study designed to evaluate the antitumor activity of brentuximab vedotin in relapsed or refractory CD30-positive NHL, including B-cell neoplasms.
- Phase II clinical trials are in progress for treatment of endometrial cancer, diffuse large B-cell lymphoma, cholangiocarcinoma, and non-Hodgkin lymphoma.
- The report shows sufficient evidence of an association with soft tissue sarcoma; non-Hodgkin lymphoma (NHL); Hodgkin disease; Chronic lymphocytic leukemia (CLL); including hairy cell leukemia and other chronic B-cell leukemias.
- Subcutaneous panniculitis-like T-cell lymphoma, is a subtype of Peripheral T-cell lymphoma.
- During David Flavell’s career in cancer research, which spans more than 35 years, he has made significant research contributions in a number of areas, most notably the development of a particular class of antibody-based drug termed immunotoxins that are capable of targeting cancer cells in the patients' body without harming normal tissues.
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