Übersetzung für 'NAD-dependent' von Englisch nach Deutsch

NAD-dependent deacetylase sirtuin-1 <Sir2, Sirt1, SIRT1>

Sirtuin-1 {n} <Sir2, Sirt1, SIRT1>biochem.

• In mutant strains of "Escherichia coli" lacking the activity of NAD-dependent malate dehydrogenase, malate oxidase is expressed.
• Other names in common use include D-galactose dehydrogenase, beta-galactose dehydrogenase, and NAD+-dependent D-galactose dehydrogenase.
• The main metabolic route in humans occurs in cytoplasm, via nonspecific NAD-dependent dehydrogenase (polyol dehydrogenase), which transforms xylitol to D-xylulose.
• Homospermidine synthase proteins (EC). Homospermidine synthase (HSS) catalyses the synthesis of the polyamine homospermidine from 2 mol putrescine in an NAD+-dependent reaction.
• One of them involves the NAD-dependent lactate dehydrogenase that directly produces D-lactate ("LdhD"), and the other is through the sequential activities of an L-specific lactate dehydrogenase followed by lactate racemase.

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• Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction.
• In 2000 the Guarente laboratory published work identifying SIR2's activity as a NAD+-dependent protein deacetylase.
• The third step is the NAD+-dependent oxidation of β-isopropylmalate catalyzed by a dehydrogenase.
• Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD+-dependent enzyme expressed in aldosterone-selective epithelial tissues such as the kidney, colon, salivary and sweat glands.
• Metabolic enzymes normally have one specific function, and in the case of UDP-glucose 6-dehydrogenase, the primary function is to catalyze the two step NAD(+)-dependent oxidation of UDP-glucose into UDP-glucuronic acid.

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• While the vast majority of farnesyl diphosphate is converted into ultimately cholesterol in animals, in insects it is apparently acting on by a diphosphatase to give farnesol, which in turn is acted on by an NAD+ dependent enzyme, farnesol/farnesal dehydrogenase in "M.
• Sirtuins are a particularly interesting target for such drugs, since activation of these NAD-dependent deacetylases extends lifespan in some animal models.
• Its enzymatic counterpart, carbamoyl phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate.
• 2 and nicotinamide adenine dinucleotide phosphate (NADP) dependent GluDH 1.4.1.4 enzymes are present in "Plasmodia"; the NAD-dependent GluDH is relatively unstable and not useful for diagnostic purposes.