|NOUN || an NKT cell | NKT cells |
NOUN article.ind sg | pl
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- Natural killer T-cells (NKT cells) can also be visualized with tetramer technology.
- They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets.
- Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells.
- Human NKT cells are a unique population and are thought to play an important role in tumor immunity and immunoregulation.
- CD1D is the human gene that encodes the protein CD1d, When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.
- The roles of specialized immunoregulatory cell types, such as regulatory T cells, NKT cells, γδ T-cells in the pathogenesis of autoimmune disease are under investigation.
- Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells.
- In mice, MZ B cells characteristically express high levels of CD1d, which is an MHC class I-like molecule involved in the presentation of lipid molecules to NKT cells.
- Group 2 CD1 molecules activate a group of T cells, known as Natural killer T cells because of their expression of NK surface markers such as CD161.
- Group 1 CD1-restricted T cells are a heterogeneous group of unconventional T cells defined by their ability to recognize antigens bound on group 1 CD1 molecules (CD1a, CD1b and CD1c) with their TCR.
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