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 Übersetzung für 'X-inactivation' von Englisch nach Deutsch
biol.
X-inactivation
X-Inaktivierung {f}
1 Übersetzung
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Übersetzung für 'X-inactivation' von Englisch nach Deutsch

X-inactivation
X-Inaktivierung {f}biol.
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Anwendungsbeispiele Englisch
  • Another theory suggests the female high tendency to get autoimmunity is due to an imbalanced X-chromosome inactivation.
  • His current research interests include genome sciences and their broad implications for medicine and society, human chromosome structure and function, X-inactivation and mechanisms of gene silencing, and the first reported development of human artificial chromosomes for studies of gene transfer and functional genomics.
  • X-inactivation (also called Lyonization, after English geneticist Mary Lyon) is a process by which one of the copies of the X chromosome is inactivated in therian female mammals.
  • Not all random X-inactivation is entirely random. Some alleles, generally mutations in the X-inactivation center on the X-chromosome have been demonstrated to confer a bias towards inactivation for the chromosome on which they sit.
  • Carrier females who have only one copy of the mutation do not usually express the phenotype, although differences in X-chromosome inactivation (known as skewed X-inactivation) can lead to varying degrees of clinical expression in carrier females, since some cells will express one X allele and some will express the other.

  • An enzyme assay is not reliable for the diagnosis of disease in females due to the random nature of X-inactivation.
  • True mosaicism should not be mistaken for the phenomenon of X-inactivation, where all cells in an organism have the same genotype, but a different copy of the X chromosome is expressed in different cells.
  • The gene that codes for PIGA is located on the X chromosome, which means that only one active copy of the gene for PIGA is present in each cell (initially, females have two copies, but one is silenced through X-inactivation).
  • As an environmentally triggered malignancy, mesothelioma tumors have been found to be polyclonal in origin, by performing an X-inactivation based assay on epitheloid and biphasic tumors obtained from female patients.
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