Übersetzung für 'scFv' von Englisch nach Deutsch

single-chain variable fragment <scFv>

variables Einzelkettenfragment {n} <scFv-Fragment>biol.

• The binding region is a modified single-chain variable fragment (scFv), and the rest of the protein can be constructed from the fragment crystallizable region (Fc) and the hinge region of an immunoglobulin G1 (IgG1).
• The variable regions of the heavy and light chains can be fused together to form a single-chain variable fragment (scFv), which is only half the size of the Fab fragment, yet retains the original specificity of the parent immunoglobulin.
• Nine years later, Fukuda and colleagues chose mRNA display method for "in vitro" evolution of single-chain Fv (scFv) antibody fragments.
• A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids.
• ” A CAR typically comprises an antibody fragment (scFv) to recognize the cancer and a modular signaling domain to activate the T cell and promote T cell multiplication and persistence.

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• The single chain variable antibody fragment (scFv) ER-5 was recently created by mutating earlier used scFVs which were used against other Mexican scorpion toxins.
• Two main strategies have been described to engineer the scFv fragments.
• The same heavy and light variable chains used for scFv construction can be used in the construction of Fab.
• This picomolar affinity binding results in the diseased cells becoming coated in CD3 co-receptor specific scFv antibody fragments that constitute the ImmTAC effector function.
• Alternatives for the antibody targeting component now include multiple smaller antibody fragments like diabodies, Fab, scFV, and bicyclic peptides.

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• These include chemically linked Fabs, consisting of only the Fab regions, and various types of bivalent and trivalent single-chain variable fragments (ScFvs).
• His group has demonstrated that a synthetically prepared cell-surface glycosphingolipid can be utilized as a panning reagent to identify fully human single chain antibodies (scFvs) that are selective for melanoma and breast tumor cells.