| NOUN | a catechol-O-methyltransferase | catechol-O-methyltransferases |
NOUN article.ind sg | pl
3 Übersetzungen
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- Catechol-O-Methyltransferase {f} <COMT> = catechol-O-methyltransferase <COMT>
- Catechol-O-Methyltransferase-Hemmer {m} <COMT-Hemmer> = catechol-O-methyltransferase inhibitor <COMT inhibitor>
- Catechol-O-Methyltransferase-Inhibitor {m} <COMT-Inhibitor> = catechol-O-methyltransferase inhibitor <COMT inhibitor>
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weitere Beispiele ...
- Entacapone is a selective, reversible catechol-"O"-methyltransferase (COMT) inhibitor that prevents the degradation of levodopa.
- Aesculetin can be transformed into scopoletin (7-hydroxy-6-methoxycoumarin) and isoscopoletin (6-hydroxy-7-methoxycoumarin) through incubation with rat liver catechol-O-methyltransferase.
- A catechol-"O"-methyltransferase (COMT) inhibitor is a drug that inhibits the enzyme catechol-"O"-methyltransferase.
- Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine.
- Catabolism of catecholamines is mediated by two main enzymes: catechol-"O"-methyltransferase (COMT) which is present in the synaptic cleft and cytosol of the cell and monoamine oxidase (MAO) which is located in the mitochondrial membrane.
- It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-"O"-methyltransferase (COMT).
- Entacapone is a selective and reversible inhibitor of the enzyme catechol-"O"-methyltransferase (COMT).
- It is degraded enzymatically via catechol O-methyltransferase (COMT) primarily in the liver and excreted in the urine as sulfated conjugates.
- In vitro, the meta-hydroxyl group of catechol is methylated by catechol-O-methyltransferase.
- The steroid is known to compete with catecholamines for binding to catechol O-methyltransferase and tyrosine hydroxylase and to directly and competitively inhibit these enzymes.
- 3-O-methyldopa is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase.
- Purpurogallin is bioactive It can inhibit 2-hydroxy and 4-hydroxyestradiol methylation by catechol-O-methyltransferase. It potently and specifically inhibits TLR1/TLR2 activation pathway.
- Quinalizarin is an inhibitor of the enzyme protein kinase CK2. It is more potent and selective than emodin. It is also a potent catechol O-methyltransferase (COMT) inhibitor.
- It is a single nucleotide polymorphism (SNP) in the "COMT" gene that codes catechol-"O"-Methyltransferase.
- MDMA is known to be metabolized by two main metabolic pathways: (1) "O"-demethylenation followed by catechol-"O"-methyltransferase (COMT)-catalyzed methylation and/or glucuronide/sulfate conjugation; and (2) "N"-dealkylation, deamination, and oxidation to the corresponding benzoic acid derivatives conjugated with glycine.
- The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2.
- Anxiety disorder appears to be a genetically inherited neurochemical dysfunction that may involve autonomic imbalance; decreased GABA-ergic tone; allelic polymorphism of the catechol-O-methyltransferase (COMT) gene; increased adenosine receptor function; increased cortisol.
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Enthält Übersetzungen von der TU Chemnitz sowie aus Mr Honey's Business Dictionary (nur Englisch/Deutsch).
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