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Übersetzung für 'L-DOPA' von Englisch nach Deutsch

levodopa <L-dopa> [L-3,4-dihydroxyphenylalanine] [C9H11NO4]

Levodopa {n} <L-DOPA> [L-3,4-Dihydroxyphenylalanin]biochem.

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L-3,4-dihydroxyphenylalanine <L-DOPA>

L-3,4-Dihydroxyphenylalanin {n} <L-DOPA>biochem.

• Levodopa {n} <L-DOPA> [L-3,4-Dihydroxyphenylalanin] = levodopa <L-dopa> [L-3,4-dihydroxyphenylalanine] [C9H11NO4]
• L-3,4-Dihydroxyphenylalanin {n} <L-DOPA> = L-3,4-dihydroxyphenylalanine <L-DOPA>

• After attending a lecture at a conference on the drug L-Dopa and its success for patients with Parkinson's disease, Sayer believes the drug may offer a breakthrough for his own group of patients.
• The direct precursor of dopamine, L-DOPA, can be synthesized indirectly from the essential amino acid phenylalanine or directly from the non-essential amino acid tyrosine.
• Levodopa (commonly referred to as L-DOPA), the dopamine precursor, is the most commonly prescribed medication for Parkinson's disease, despite controversy concerning the neurotoxicity of dopamine and L-DOPA.
• The S-enantiomer of methyldopa is a competitive inhibitor of the enzyme aromatic L-amino acid decarboxylase (LAAD), which converts L-DOPA into dopamine.
• Carbidopa inhibits aromatic-L-amino-acid decarboxylase (DOPA decarboxylase or DDC), an enzyme important in the biosynthesis of L-tryptophan to serotonin and in the biosynthesis of L-DOPA to dopamine (DA).

• The long term use of L-Dopa increases oxidative stress through monoamine oxidase led enzymatic degradation of synthesized dopamine causing neuronal damage and cytotoxicity.
• The use of L-DOPA in patients can lead to interruption of nigrostriatal dopamine projections as well as changes in the post-synaptic neurons in the basal ganglia.
• Drug holidays from L-dopa found use in the early 1970s when Sweet et al.
• One of the first major successes in using chemicals to alter brain function was the L-DOPA experiment.
• In contrast, non-proteinogenic amino acids are amino acids that are either not incorporated into proteins (like GABA, L-DOPA, or triiodothyronine), misincorporated in place of a genetically encoded amino acid, or not produced directly and in isolation by standard cellular machinery (like hydroxyproline).

• Knowles was also the first to apply enantioselective metal catalysis to industrial-scale synthesis; while working for the Monsanto Company he developed an enantioselective hydrogenation step for the production of L-DOPA, utilising the DIPAMP ligand.
• In normal dopamine and serotonin (5-HT) neurotransmitter synthesis, AADC is not the rate-limiting step in either reaction.
• It is thought that Parkinson's disease is caused by degradation of the dopaminergic mesocorticolimbic projection originating from the ventral tegmental area.