2 Übersetzungen
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- luteinisierendes Hormon-freisetzendes Hormon {n} <LHRH> = luteinizing hormone-releasing hormone <LHRH>
- luteinisierendes Hormon-freisetzendes Hormon {n} <LHRH> = luteinising-hormone releasing hormone <LHRH> [Br.]
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- Produced in hypothalamic astrocytes, TGF-α indirectly stimulates LHRH release through various intermediates.
- GnRH2, also known as gonadotropin-releasing hormone II or LHRH-II. Its gene is located on human chromosome 20.
- Antiandrogens such as cyproterone acetate and medroxyprogesterone acetate, or the LHRH agonist leuprolide, are sometimes prescribed to convicted male sex offenders who are released on parole in an effort to stop them reoffending, in a treatment sometimes referred to as chemical castration, however the high doses required often cause a range of side effects which may limit compliance.
- In 1992, he co-authored one of the first QOL studies examining patient preference related to LHRH versus orchiectomy for patients with advanced disease.
- The alleged advantages of these compounds were that they did not affect libido or potency like the other centrally acting compounds under development, luteinizing-hormone-releasing hormone (LHRH) agonists and cyproterone acetate.
- Orchiectomy, LHRH analogs and LHRH antagonists can all cause similar side effects, due to changes in the levels of sex hormones (testosterone).
- The proposed method of action is that upon administration zoptarelin doxorubicin binds to the LHRH receptor and is subsequently internalized, concentrating the toxic doxorubicin within cancer cells and the small subset of normal tissues, as opposed to the completely systemic distribution observed with untargeted chemotherapeutics.
- Some noteworthy accomplishments include the development of TRH analogs, LHRH antagonists and the development of a new class of small synthetic peptides (GHRPs, growth hormone releasing peptides) that specifically release growth hormone in animals and humans.
- The amount of androgen will accumulate at a very high rate in the blood, disrupting the LHRH-LH/FSH axis that can potentially lead to polycystic ovaries in adulthood.
- There is no standard medical therapy; agents reported to be effective in case reports include systemic hormonal therapy with SERMs such as tamoxifen or LHRH agonists (leuprolide), and cytotoxic ("traditional") chemotherapy, as well as radiation therapy especially for recurrent disease.
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