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Übersetzung für 'dTTP' von Englisch nach Deutsch

deoxythymidine triphosphate <dTTP>

Desoxythymidintriphosphat {n} <dTTP>biochem.

• Desoxythymidintriphosphat {n} <dTTP> = deoxythymidine triphosphate <dTTP>

• This function contributes to DNA replication and repair via de novo thymidylate biosynthesis, as the dUMP product is methylated by thymidylate synthase (TS) to form dTMP, which is then phosphorylated to dTTP.
• Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.
• Thus, the two substrates of this enzyme are dTTP and H2O, whereas its two products are dTDP and phosphate.
• This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP.
• Phage T7 has the simplest known DNA replisome, consisting of a helicase and primase that reside in a single polypeptide chain that forms a hexamer in the presence of DNA and ATP or dTTP.

• Deoxythymidine can be phosphorylated with one, two or three phosphoric acid groups, creating dTMP (deoxythymidine monophosphate), dTDP, or dTTP (for the di- and tri- phosphates, respectively).
• This process starts from glucose-1-phosphate where NovV takes dTTP and replaces the phosphate group with a dTDP group.
• Thymidine can be phosphorylated with up to three phosphoric acid groups, producing dTMP (deoxythymidine monophosphate), dTDP, or dTTP (for the di- and tri- phosphates, respectively).
• Researchers propose that it is involved in attenuating interferon response, but it also contains a dTTP-binding site which may be used for cap-snatching.
• 23 million square feet (393,000 square meters) under a single roof, the DTTP is the third largest factory in the United States (behind the Tesla Factory and the Boeing Everett Factory) and the fifth largest in the world.

• The protein mdN is essential to counteract dTTP accumulation, as excess dTTP has been linked to mitochondrial genetic disease.
• The homologue in DNA is thymidine triphosphate (TTP or dTTP). UTP also has a deoxyribose form (dUTP).
• Thymineless death is the phenomenon by which bacteria, yeasts and mammalian cells undergo cell death when they are starved of thymidine triphosphate (dTTP), an essential precursor for DNA replication.
• The downstream effect is promotion of cell death because cells would not be able to properly undergo DNA synthesis if they are lacking dTMP, a necessary precursor to dTTP.