⇄SuchrichtungÜbersetzung für 'NMDAR' von Englisch nach Deutsch
NMDA receptor <NMDAR>
NMDA-Rezeptor {m}
1 Übersetzung
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Übersetzung für 'NMDAR' von Englisch nach Deutsch

NMDA receptor <NMDAR>
NMDA-Rezeptor {m}biochem.
Anwendungsbeispiele Englisch
  • In December 2020, Novartis announced it would acquire Cadent Therapeutics for up to $770 million, gaining full rights to CAD-9303 (a NMDAr positive allosteric modulator), MIJ-821 (a NMDAr negative allosteric modulator) and CAD-1883 a clinical-stage SK channel positive allosteric modulator.
  • The NMDA receptor (NMDAR) does not, in resting or near-resting membrane potential conditions, contribute significant current to the EPSP.
  • D-serine is a potent agonist at the glycine site (NR1) of the NMDA-type glutamate receptor (NMDAR).
  • AP-7 is a selective NMDA receptor (NMDAR) antagonist that competitively inhibits the glutamate binding site and thus activation of NMDAR. It has anticonvulsant effects.
  • The NMDAR/TRPM4 complex is considered central to glutamate excitotoxicity.
  • Hilmar Bading and his co-workers uncovered the importance of a death signaling complex consisting of extrasynaptic NMDA receptors (NMDARs) and TRPM4 for excitotoxicity and identified a class of neuroprotective small molecules (known as NMDAR/TRPM4 interaction interface inhibitors or short ‚interface inhibitors‘) that disrupt the NMDAR/TRPM4 complex and protect against cell death in mouse models of stroke and retinal ganglion cell degeneration.
  • Mice with only 5% of the normal levels of NMDAR's expressed schizophrenic-like behaviors seen in animal models of schizophrenia while mice with 100% of NMDAR's behaved normally.
  • Autapses have been used to simulate "same cell" conditions to help researchers make quantitative comparisons, such as studying how "N"-methyl-D-aspartate receptor (NMDAR) antagonists affect synaptic versus extrasynaptic NMDARs.
  • It has been suggested that NMDA receptors (NMDARs) in the amygdala are necessary for fear memory acquisition, because disruption of NMDAR function disrupts development of fear responses in rodents.
  • NMDAR activity reduces phosphorylation of β-catenin at tyr-654, thereby inhibiting N-cadherin endocytosis and facilitating surface retention and expression.
  • The inhibition of NMDAR-mediated spontaneous EPSCs (sEPSCs) and NMDA-gated currents in cortical neurons might be a result of actions on both diheteromeric (NR1/NR2B) and triheteromeric (NR1/NR2A/NR2B) NMDAR.
  • In a largescale phospho screening of the PSD, it was found to be phosphorylated following activation of the NMDAR complex.
  • FPL 14467 ("p"- [...]) is inactive "in vivo" and weak in binding NMDAR.
  • Herpes simplex virus-1 encephalitis appears to be a trigger for anti-NMDAR encephalitis; most AIE cases after herpes zoster are now believed to be anti-NMDAR encephalitis.
© dict.cc English-German dictionary 2023
Enthält Übersetzungen von der TU Chemnitz sowie aus Mr Honey's Business Dictionary (nur Englisch/Deutsch).
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