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 Übersetzung für 'arachidonate' von Englisch nach Deutsch
NOUN   an arachidonate | arachidonates
biochem.
arachidonate
Arachidonat {n}
1 Übersetzung
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Übersetzung für 'arachidonate' von Englisch nach Deutsch

arachidonate
Arachidonat {n}biochem.
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Anwendungsbeispiele Englisch
  • Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the "ALOX15B" gene.
  • The 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA.
  • ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products.
  • Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes.
  • In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation.

  • Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the "ALOX5AP" gene.
  • Arachidonate 5-lipoxygenase has been identified as playing a significant role in the survival of prostate cancer cells. Medications that target this enzyme are undergoing development.
  • If arachidonate is acted upon by a lipoxygenase instead of cyclooxygenase, Hydroxyeicosatetraenoic acids and leukotrienes are formed. They also act as local hormones.
  • Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase.
  • It is also an inhibitor of neuronal nitric oxide synthase (NOS), CYP-dependent (cytochrome P450-dependent) arachidonate metabolism, transmembrane calcium influx, and platelet thromboxane synthesis.

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