| NOUN | an eicosanoid | eicosanoids |
NOUN article.ind sg | pl
2 Übersetzungen
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Anwendungsbeispiele Englisch
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- This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect.
- A prostaglandin antagonist is a hormone antagonist acting upon one or more prostaglandins, a subclass of eicosanoid compounds which function as signaling molecules in numerous types of animal tissues.
- (See article eicosanoid receptors for more information).
- Other lipoxygenases—8-LO, 12-LO and 15-LO—make other eicosanoid-like products.
- In addition to their inflammatory nature, eicosanoid molecules such as ETA can also contribute to an anti-inflammatory response.
- Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator.
- Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase.
- Omega-3 fatty acids contribute to the production of eicosanoid molecules that reduce clotting.
- Serinolamide A is a naturally occurring eicosanoid derivative related to anandamide, which has been isolated from the marine cyanobacteria "Lyngbya majuscula" and related species in the "Oscillatoria" family.
- O-1812 is an eicosanoid derivative related to anandamide that acts as a potent and highly selective agonist for the cannabinoid receptor CB1, with a "K"i of 3.4 nM at CB1 and 3870 nM at CB2.
- For further details of these and other hydroxeicosatetraenoic acids, e.g. 18-HETE, 17-HETE, and 16-HETE, see eicosanoid and lipoxygenase pages.
- Arachidonic acid (AA; 20:4 ω-6) sits at the head of the "arachidonic acid cascade" – more than twenty eicosanoid-mediated signaling paths controlling a wide array of cellular functions, especially those regulating inflammation, immunity, and the central nervous system.
- Arachidonic acid (with its precursor – linoleic acid) serves as a substrate to the production of inflammatory mediators known as eicosanoids, whereas the arachidonic acid-containing compound diacylglycerol (DAG) is a precursor to the endocannabinoid 2-arachidonoylglycerol (2-AG) while fatty acid amide hydrolase (FAAH) mediates the metabolism of anandamide into arachidonic acid.
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