Übersetzung für 'leflunomide' von Englisch nach Deutsch

leflunomide

Leflunomid {n}pharm.

• The immunomodulatory drugs teriflunomide and leflunomide have been shown to inhibit DHODH.
• Examples include Leflunomide and Teriflunomide (the active metabolite of leflunomide).
• Use of rituximab and leflunomide have been proposed.
• Teriflunomide is the main active "in vivo" metabolite of leflunomide.
• There are no dosing guidelines for leflunomide in BKVAN. Patient to patient variability has made dosing and monitoring of leflunomide extremely difficult.

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• This revealed that an inhibition of the DHODH protein (by a small molecule called leflunomide) prevented development of the neural crest stem cells which ultimately give rise to melanoma via interference with the process of transcriptional elongation.
• In some cases, methotrexate or leflunomide may be helpful.
• Less toxic immunosuppressing medications such as rituximab, methotrexate, azathioprine, leflunomide, or mycophenolate mofetil are used.
• The most commonly used agent is methotrexate with other frequently used agents including sulfasalazine and leflunomide.
• See leflunomide for information on pharmacokinetics, side effects, contraindications and other data.

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• Immunosuppressive agents include T-cell inhibitors such as cyclosporine and tacrolimus; antimetabolites such as azathioprine, methotrexate, mycophenolate mofetil, and leflunomide; alkylating agents such as cyclophosphamides and chlorambucil; and biological drugs such as adalimumab.