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Anwendungsbeispiele Englisch
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- Investigators found that HSPGs such as perlecan and collagen type XVIII are modified during human renal ischemia/reperfusion, which is associated with severe endothelial damage.
- and Perlecan.
- FGF7 has been shown to interact with Perlecan.
- Intraglomerular mesangial cells synthesize and secrete the extracellular matrix. It contains fibronectin, type IV collagen, perlecan, and laminin.
- In the extracellular matrix, especially basement membranes and fractones, the multi-domain perlecan, agrin and collagen XVIII core proteins are the main HS-bearing species.
- In a mouse model of Alzheimer's plaque formation, IL-1-alpha effects an increase in perlecan expression in response to brain injury.
- For example, perlecan degradation can yield endorepellin which functions as an anti-angiogenic factor.
- Structurally it (along with perlecan) connects the networks formed by collagens and laminins to each other.
- Reddy's spun off its drug discovery and research wing into a separate company called Perlecan Pharma Private Limited.
- Transthyretin has been shown to interact with Perlecan.
- Schwartz–Jampel syndrome (SJS) is a rare genetic disease caused by a mutation in the perlecan gene ("HSPG2") which causes osteochondrodysplasia associated with myotonia.
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