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Übersetzung für 'prothrombinase' von Englisch nach Deutsch

prothrombinase

Prothrombinase {f}biochem.

• Prothrombinase {f} = prothrombinase

• Normally when a vascular injury occurs, platelets are activated and phosphatidylserine (PS) in the inner leaflet of the platelet membrane is transported to the outer leaflet of the platelet membrane, where it provides a binding site for plasma protein complexes that are involved in the conversion of prothrombin to thrombin, such as factor VIIIa-IXa (tenase) and factor Va-Xa (prothrombinase).
• Membrane bound FGL2 (mFGL2) exhibits a prothrombinase activity, resulting in fibrin deposition, vascular thrombosis and tissue inflammation within an affected tissue, largely contributing to the innate arm of immunity.
• These phospholipids then bind the tenase and prothrombinase complexes, two of the sites of interplay between platelets and the coagulation cascade.
• Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex.
• This "tenase" complex activates more Factor X, which in turn forms new prothrombinase complexes with Factor Va.

• 2), is a polypeptide fragment of prothrombin (factor II) generated by the "in vivo" cleavage of prothrombin into thrombin (factor IIa) by the enzyme prothrombinase (a complex of factor Xa and factor Va).
• In coagulation, uninhibited factor Xa forms a prothrombinase complex with factor Va on platelet surfaces.