⇄SuchrichtungÜbersetzung für 'topotecan' von Englisch nach Deutsch
NOUN   topotecan | -
Topotecan {n}
1 Übersetzung
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Übersetzung für 'topotecan' von Englisch nach Deutsch

Topotecan {n}pharm.
Anwendungsbeispiele Englisch
  • Amrubicin acts by inhibiting topoisomerase II, and has been compared in clinical trials with topotecan, a Topoisomerase I inhibitor.
  • Liposomal lurtotecan was in clinical trials as a treatment for topotecan-resistant ovarian cancer, but was discontinued.
  • Camptothecin analogues irinotecan and topotecan, which inhibit TOP1, are among the most effective FDA-approved anticancer chemotherapeutic agents used in clinical practice.
  • It is water-soluble and more potent than topotecan.
  • Chemotherapy with topotecan and cyclophosphamide is frequently used in refractory setting and after relapse.
  • ABCG2 can export anthracycline anticancer drugs, as well as topotecan, mitoxantrone, or doxorubicin as substrates.
  • In 2001, Inex was developing topotecan with GlaxoSmithKline and by 2004 was in the research stage of preparing their own targeted cancer vaccine program.
  • It varies from other camptothecin based Top1 inhibitors like topotecan in having a 7-membered E-ring.
  • In 2018, an Independent Data Monitoring Committee found that in the TAHOE phase III trial, Rova-T shortened survival of lung cancer patients compared to SOC chemotherapy topotecan, prompting termination of trial enrollment.
  • BMS manufactures paclitaxel using "Penicillium" and plant cell fermentation. Fungi can synthesize podophyllotoxin and camptothecin, precursors to etoposide, teniposide, topotecan, and irinotecan.
  • The cancer treatment drug topotecan is a synthetic chemical compound similar in chemical structure to camptothecin which is found in extracts of "Camptotheca" (happy tree).
  • Administration of topotecan down-regulates its target, topoisomerase-I; therefore, it is dosed to maximize efficacy and minimize related toxicity.
  • For patients who relapse in < 6 months, single-agent chemotherapy either topotecan second-line therapy, or paclitaxel can be used.
  • Inex had been developing liposomal formulations of off-patent cancer drugs, and licensed them to Talon Pharmaceuticals in 2005; Talon was acquired by Spectrum Pharmaceuticals in 2013, and three former Inex/Tekmira products reached the market and began generating royalties for Tekmira: Marqibo (liposomal vincristine), Alocrest (liposomal vinorelbine) and Brakiva (liposomal topotecan).
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Enthält Übersetzungen von der TU Chemnitz sowie aus Mr Honey's Business Dictionary (nur Englisch/Deutsch).
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