Übersetzung für 'ubiquitinated' von Englisch nach Deutsch

ubiquitinated {adj} {past-p}

ubiquitiniertbiochem.

• ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular bodies (MVBs).
• In addition to the regulation of HIF1α, pVHL regulates USP20. USP20 binds to the β-domain of pVHL and is subsequently ubiquitinated. This signals USP20 for degradation via the proteasome.
• TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the "TNIP2" gene. TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.
• A nuclear complex containing FANCE protein (as well as FANCC, FANCF and FANCG) is essential for the activation of the FANCD2 protein to the mono-ubiquitinated isoform.
• Signal transducing adapter molecule 1 is a protein that in humans is encoded by the "STAM" gene. STAM1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.

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• TAB1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.
• The ubiquitinated WNK1 will subsequently undergo proteasomal degradation.
• A nuclear complex containing FANCC protein (as well as FANCA, FANCF and FANCG) is essential for the activation of the FANCD2 protein to the mono-ubiquitinated isoform.
• HDAC6 bonds with high affinity to ubiquitinated proteins.
• Histones are often ubiquitinated with one ubiquitin molecule (monoubiquitination), but can also be modified with ubiquitin chains (polyubiquitination), both of which can have variable effects on gene transcription.

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• Overexpression or inhibition of proteasome activity in transfected human embryonic kidney cells or Chinese hamster ovary cells leads to the accumulation of stable, high molecular weight, detergent-insoluble, multi-ubiquitinated forms of CFTR.
• The bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquitinated, or bound by other proteins such as heat shock proteins, or p62/Sequestosome 1.
• Inhibition of USP27X would cause Snail1 to be ubiquitinated and then degraded, and therefore it would impair EMT.
• Without efficient autophagy, neurons gather ubiquitinated protein aggregates and degrade.
• When receptors are active, they are ubiquitinated and GPR56 lacking an N-terminus was highly ubiquitinated.

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• Proteins that are ubiquitinated are delivered to the JUNQ, where they are processed for degradation by the proteasome.
• Chk1 and Chk2 phosphorylate Cdc25, inhibiting its phosphorylating activity and marking it for ubiquitinated degradation.
• Tubulin is also known to be phosphorylated, ubiquitinated, sumoylated, and palmitoylated.
• Multivesicular bodies play a large role in the transport of ubiquitinated proteins and receptors to a lysosome.