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- Amyloid-beta {n} <Aβ> [Amyloid-beta 40 (Aβ40), Amyloid-beta 42 (Aβ42)] = amyloid beta <Aβ, Abeta>
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- Buildup of beta amyloid (Aβ) peptides is shown to cause and/or trigger Alzheimer's disease.
- Researchers at the University of Toronto have found that "scyllo"-inositol can block the development of amyloid-beta (Aβ) plaques in the brains of transgenic mice.
- This activity was observed over sixty years ago, These findings suggest that IDE activity is capable of joining of several Aβ fragments together.
- Bapineuzumab, a humanized anti-Aβ mAb, is directed against the N-terminus of Aβ.
- Aβ proteins form antiparallel β sheets which are strongly amphiphilic, and which aggregate to form toxic oxidative Aβ fibrils.
- The normal function of Aβ is not certain, but plaques arise when the protein misfolds and begins to accumulate in the brain by a process of molecular templating ('seeding').
- the Aβ*56 oligomer was one of many being explored at the time ...
- Her lab demonstrated that cathepsin B (CatB) can degrade Aβ, the hallmark protein aggregate in AD.
- There is evidence that Aβ has antioxidant properties (Hayashi et al. ...
- Nonspecific Aβ channel blockers including tromethamine (Tris) and Zn2+ have successfully inhibited Aβ cytotoxicity.
- Amyloid plaques formed by amyloid-β (Aβ) deposition and neurofibrillary tangles formed by tau protein phosphorylation are dominant physiological features of Alzheimer's disease.
- Type Aβ fibres, and type Aγ, are the "type II" afferent fibers from stretch receptors.
- Additionally, researchers have recently discovered a new mechanism (which involves LTD) linking soluble amyloid beta protein (Aβ) with the synaptic injury and memory loss related to AD.
- Alzheimer's is associated with toxic aggregations of the amyloid beta (Aβ) peptide, caused by Aβ misfolding and clumping together with other Aβ peptides.
- The machine contains p+2 deterministic finite automaton and a master controller, where p is the size of Aβ*.
- Examples of failed translational research in the pharmaceutical industry include the failure of anti-aβ therapeutics in Alzheimer's disease.
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