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Übersetzung für 'Allopurinol' von Englisch nach Deutsch

allopurinol [C5H4N4O]

Allopurinol {n}pharm.

• Allopurinol {n} = allopurinol [C5H4N4O]

• Concomitant treatment with certain other medications (including allopurinol, H2 receptor antagonists, lincosamide antibiotics, macrolide antibiotics, and propranolol) can decrease the hepatic clearance of doxofylline, which can result in increased serum levels of doxofylline.
• Because allopurinol is not a uricosuric, it can be used in people with poor kidney function.
• HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome.
• Febuxostat is typically recommended only for people who cannot tolerate allopurinol.
• Ampicillin causes skin rashes more often when given with allopurinol.

• Urate stones can be dissolved using a diet with reduced purines that alkalinizes and dilutes the urine. Allopurinol is used in dogs with altered purine metabolism to prevent the formation of uric acid.
• Patients at risk for acute uric acid nephropathy can be given allopurinol or rasburicase (a recombinant urate oxidase) prior to treatment with cytotoxic drugs.
• Persistent elevation of uric acid above 6.5 mg/dl warrants treatment with allopurinol to prevent uric acid deposition in kidneys and joints.
• While historically it is not recommended to start allopurinol during an acute attack of gout, this practice appears acceptable.
• Fluorouracil's efficacy is decreased when used alongside allopurinol, which can be used to decrease fluorouracil induced stomatitis through use of allopurinol mouthwash.

• Hydroxychavicol is a phenylpropanoid compound present in leaves of "Piper betle". It is a more potent inhibitor of xanthine oxidase (IC50=16.7 µM) than allopurinol.
• Lesinurad/allopurinol (trade name Duzallo) is a fixed-dose combination drug for the treatment of gout.
• Based on the Asian findings, similar studies in Europe showed 61% of allopurinol-induced SJS/TEN patients carried the HLA-B58 (phenotype frequency of the B*5801 allele in Europeans is typically 3%).
• Patients with hyperleukocytosis associated with leukemia are always considered candidates for tumor lysis syndrome prophylaxis in addition to aggressive intravenous hydration with allopurinol or rasburicase to decrease serum uric acid levels.