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Übersetzung für 'Encorafenib' von Englisch nach Deutsch

encorafenib [C22H27ClFN7O4S]

Encorafenib {n}pharm.

• Encorafenib {n} = encorafenib [C22H27ClFN7O4S]

• More general B-Raf inhibitors include GDC-0879, PLX-4720, Sorafenib, dabrafenib and encorafenib.
• Vemurafenib, encorafenib, and dabrafenib are approved by the FDA for treatment of metastatic melanomas that express V600E.
• In June 2018 it was approved by the FDA in combination with encorafenib for the treatment of patients with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma.
• Encorafenib acts as an ATP-competitive RAF kinase inhibitor, decreasing ERK phosphorylation and down-regulation of CyclinD1.