Übersetzung für 'NMDA antagonists' von Englisch nach Deutsch

N-methyl-D-aspartate antagonists <NMDA antagonists>

N-Methyl-D-Aspartat-Antagonisten {pl} <NMDA-Antagonisten>pharm.

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NMDA receptor <NMDAR>

NMDA-Rezeptor {m}biochem.

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antagonists

Antagonisten {pl}

Widersacher {pl}

hormone antagonists

Hormonantagonisten {pl}pharm.

receptor antagonists

Rezeptorantagonisten {pl}pharm.

dopamine antagonists

Dopamin-Antagonisten {pl}pharm.

calcium antagonists

Calciumantagonisten {pl}pharm.

H2-receptor antagonists

H2-Rezeptorantagonisten {pl}pharm.

folic acid antagonists

Folsäureantagonisten {pl}chem.

angiotensin II receptor antagonists

Angiotensin-II-Rezeptor-Antagonisten {pl}pharm.

• Alterations in production of endogenous NMDA antagonists such as agmatine and kynurenic acid have been shown in schizophrenia.
• Siramesine has been shown to produce an enhanced antidepressant effect when co-administered with NMDA antagonists.
• Afterglow may also occur after the usage of dissociative drugs, such as the NMDA antagonists, DXM, ketamine and PCP.
• Conversely, coadministration of NMDA-antagonists with alpha-2 adrenergic antagonists, like yohimbine, could theoretically potentiate NAN.
• when first-line treatment options fail, NMDA antagonists such as amantadine or memantine may be used.

• The use of D-methionine to protect against hearing loss induced by drugs like cisplatin and aminoglycosides is preliminarily supported by animal studies. NMDA antagonists are also shown to limit aminoglycosides-induced ototoxicity.
• This hypothesis was corroborated by evidence that NMDA antagonists have antidepressant effects in rodents.
• Cytotoxicity can be blocked by noncompetitive NMDA antagonists, such as dextrorphan and MK-801.
• Gavestinel is an NMDA antagonist, binding selectively to the glycine site on the NMDA receptor complex, rather than the glutamate site many NMDA antagonists bind to.
• In animal models, NMDA antagonists increase glutamate release in the prefrontal cortex.

• Researchers have examined many different NMDA antagonists and their therapeutic efficacy, none of which have concluded to be both safe and effective.
• In 1989, John Olney discovered that neuronal vacuolation and other cytotoxic changes ("lesions") occurred in brains of rats administered NMDA antagonists, including PCP and ketamine.
• Dextromethorphan (the stereoisomer of levomethorphan, a semi-synthetic opioid agonist) and its metabolite dextrorphan have no opioid analgesic effect at all despite their structural similarity to other opioids; instead they are potent NMDA antagonists and sigma 1 and 2-receptor agonists and are used in many over-the-counter cough suppressants.