Übersetzung für 'P selectin' von Englisch nach Deutsch

P-selectin

P-Selectin {n}biochem.

P-Selektin {n}biochem.

---

Werbung

P-selectin molecule

P-Selectinmolekül {n}biochem.

P-selectin molecules

P-Selectinmoleküle {pl}biochem.

• HIF-1 and EGR-1 pathways lead to monocyte association with endothelial proteins, such as P-selectin, prompting monocytes to release tissue factor-filled microvesicles, which presumably initiate fibrin deposition (via thrombin) after binding the endothelial surface.
• For example, the carbohydrate ligand for P-selectin, P-selectin glycoprotein ligand-1 (PSGL-1), is expressed by different types of leukocytes (white blood cells).
• They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin).
• The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis.
• Biodegradable particles bearing ligands to P-selectin, endothelial selectin (E-selectin) and ICAM-1 have been found to adhere to inflamed endothelium.

  ---

• This indicates that sulfatide may serve as a specific ligand for P-selectin.
• P-selectin has a similar function, but is expressed on the endothelial cell surface within minutes as it is stored within the cell rather than produced on demand.
• P-selectin release from Weibel-Palade bodies, on blood vessel endothelial cells, can be induced by a number of factors.
• During an inflammatory response, P-selectin is expressed on endothelial cells first, followed by E-selectin later.
• SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes.

  ---

• A Tel Aviv University study showed that pharmacological and molecular inhibition of the P-selectin protein leads to reduced tumor growth and increased survival in mouse models of glioblastoma.
• Sialyl-Lewisx is a necessary partner for the three selectins that bind the leukocyte and endothelial cells.
• The selectins are a family of heterophilic CAMs that are dependent on fucosylated carbohydrates, e.g., mucins for binding.