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 ⇄Suchrichtung
 Übersetzung für 'PXR' von Englisch nach Deutsch
biochem.
pregnane X receptor <PXR>
Pregnan-X-Rezeptor {m} <PXR>
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 ⇄ 
Übersetzung für 'PXR' von Englisch nach Deutsch

pregnane X receptor <PXR>
Pregnan-X-Rezeptor {m} <PXR>biochem.
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  • Pregnan-X-Rezeptor {m} <PXR> = pregnane X receptor <PXR>
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Anwendungsbeispiele Englisch
  • The expression of the oxidase gene can be upregulated by the steroid sensor PXR when there is a high blood concentration of steroids.
  • One of the primary targets of PXR activation is the induction of CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs.
  • Environmental Protection Agency (EPA) and the University of New Hampshire investigated the effect of DE-71, a commercial PBDE mixture, on PEPCK enzyme kinetics and determined that in vivo treatment of the environmental pollutant compromises liver glucose and lipid metabolism possibly by activation of the pregnane xenobiotic receptor (PXR), and may influence whole-body insulin sensitivity.
  • DHEA does not bind to or activate the progesterone, glucocorticoid, or mineralocorticoid receptors. However, whereas DHEA is a ligand of the PPARα and PXR in rodents, it is not in humans.
  • Spironolactone is an agonist of the pregnane X receptor (PXR), a xenobiotic-sensing receptor.

  • This contributes to an increase in plasma protein binding and a reduction of activation of the pregnane X receptor (PXR).
  • In any case, 5β-DHP has nonetheless been shown to possess tocolytic effects in animals, and this may alternatively be mediated by activation of the PXR.
  • Ekins has also carried out independent research and collaborative research on topics including pharmacophores for drug transporters, cheminformatics for predicting immunoassay cross reactivity, models for studying nuclear receptor-ligand co-evolution, computational models for PXR agonists and antagonists as well as analyses of large datasets and crowdsourcing data.
  • Pxr homologs have only been found in one other taxon, namely "Stigmatella aurantiaca".
  • CAR can also impact gluconeogenesis regulation mediated by a transcription factor; the transcription factor binding can be regulated to Insulin Response Sequence(IRS). PXR protects the body from bile acid toxicity.

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