Übersetzung für 'T suppressor cell' von Englisch nach Deutsch

suppressor T-cell

T-Unterdrückerzelle {f}biol.

suppressor T-cell <Tsupp> [dated] [regulatory T-cell]

Suppressor-T-Zelle {f} <TSupp> [veraltet] [regulatorische T-Zelle]biol.

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T-suppressor cell

T-Suppressorzelle {f}biol.

• ... lung cancer) showed that they are tolerated and safe, but on the other hand, some studies report that γδ T cells cause cancer development for example through production of IL-17 in tumor microenvironment, which promotes angiogenesis and cell growth or because their ability to increase numbers of myeloid derived suppressor cells.
• They are also able to induce suppressor molecules that can inhibit T cell reproduction.
• There is also the unlikely possibility that the engineered CAR T-cells will themselves become transformed into cancerous cells through insertional mutagenesis, due to the viral vector inserting the CAR gene into a tumor suppressor or oncogene in the host T cell's genome.
• Non-activated (immature) DCs are usually located in the peripheral non-lymphoid tissues and they can present self-antigens to T cells, that leads to immune tolerance either through T cell deletion or through the differentiation of regulatory T cells or suppressor T cells.
• V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the "C10orf54" gene.

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• Preclinical mice studies implicate CAFs, TAMs and myelomonocytic cells (including several myeloid-derived suppressor cells (MDSCs)) in restricting T cell accumulation near cancer cells.
• Infections of chickens with avian reovirus doesn't disrupt the functional capabilities of their T-cells, but induces suppressor macrophages that inhibit T-cell function.
• PSGL-1 has been shown to bind to VISTA (V-domain Ig suppressor of T cell activation) but this binding only occurs under acidic pH conditions (pH < 6.5) such as can be found in tumor microenvironments (TME).
• Using the El Dorado program from Genomatix, transcription factor regulation was predicted, which found that ‘’TMEM63A’’ is highly regulated by E2F cell cycle regulators and EGR1, a factor believed to be a tumor suppressor gene with expression in the brain.
• The mechanisms behind are supposed to be reduced suppressor activity of T regulatory cells and changes in cytokine environment.

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• Capsaicin reduces the expression of anti-apoptotic protein Bcl-2 and it also promotes activation of p53, a tumour-suppressor protein known as a major regulator of cell death.
• Immortal cell lines of cancer cells can be created by induction of oncogenes or loss of tumor suppressor genes.
• This gene is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor.
• The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line.
• A significant number of individuals with mutations on the "rb" tumor suppressor gene have also developed the tumor.

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• Researchers have identified an increase of suppressor of cytokine signaling 3 (SOCS3) in a large number of STAT GOF patients.