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 ⇄Suchrichtung
 Übersetzung für 'ZFN' von Englisch nach Deutsch
biochem.
zinc finger nuclease <ZFN>
Zinkfingernuklease {f} <ZFN>
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 ⇄ 
Übersetzung für 'ZFN' von Englisch nach Deutsch

zinc finger nuclease <ZFN>
Zinkfingernuklease {f} <ZFN>biochem.
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  • Zinkfingernuklease {f} <ZFN> = zinc finger nuclease <ZFN>
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Anwendungsbeispiele Englisch
  • A major advantage of ZFN- and TALEN-mediated gene knockout relative to the use of mobile DNA is that a particular gene can be uniquely and specifically targeted for knockout.
  • A knockout zebrafish line was generated in 2014 using the zinc-finger nuclease (ZFN)-mediated targeted gene editing system.
  • Recently, a group of researchers have successfully applied the ZFN technology to genetically modify the gol pigment gene and the ntl gene in zebrafish embryo.
  • In the study, the frequency of HR-based GT using a zinc-finger nuclease (ZFN) was increased up to sixteen times in "ku70" mutants This result has promising implications for genome editing across eukaryotes as DSB repair mechanisms are highly conserved.
  • Compared to CRISPR/Cas9, the therapeutic applications of this technology are limited, due to the extensive engineering required to make each ZFN specific to the desired sequence.

  • Sangamo Therapeutics, headquartered in Richmond, California, is currently conducting a clinical trial involving gene editing using Zinc Finger Nuclease (ZFN) for the treatment of MPS I.
  • A phase I/II clinical trial enrolled 12 patients with acquired immune deficiency syndrome (AIDS) to test the safety and effectiveness of administering ZFN-modified autologous helper T cells.
  • Another method used by the Kiem lab was the release of zinc finger nuclease (ZFN), which identifies specific sections of DNA to cause a break in the double helix.
  • In July 2009, the first genetically modified mammal was created through the use of CompoZr ZFN Technology.
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