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- indica" is being used to study how asymmetric cell-division during mitosis results in clonal cell heterogeneity.
- Age and (CTG)n length only have small correlation coefficients to disease progression, research suggests that various other factors play a role in disease progression such as changes in signal transduction pathway, somatic expression, and cell heterogeneity in (CTG)n repeats.
- In cancer research, cancer cell heterogeneity is thought to be one of the underlying reasons that make treatment of cancer difficult.
- Cancers in particular are characterized by single-cell heterogeneity, which can drive metastasis and treatment resistance. The mechanisms that underlie these processes are still largely unknown, although the advent of single-cell technologies, including single-cell epigenomics, has contributed greatly to their elucidation.
- Certain level of cell-to-cell heterogeneity was observed, suggesting a large degree of stochasticity in replication origin firing in early S phase.
- Cancer cell heterogeneity can cause disease progression when molecularly targeted therapy, fails to kill those tumor cells which do not express the marker, then divide and mutate further, creating a new heterogeneous tumour.
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