Übersetzung für 'heterotrimeric G protein' von Englisch nach Deutsch

heterotrimeric G protein

heterotrimeres G-Protein {n}biochem.

• GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.
• In vitro studies on GPR156 constitutive activity revealed a high level of basal activation and coupling with members of the Gi/Go heterotrimeric G protein family.
• The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase.
• The first function as monomeric small GTPases (small G-proteins), while the second function as heterotrimeric G protein complexes.
• Heterotrimeric G protein complexes are composed of three distinct protein subunits named "alpha" (α), "beta" (β) and "gamma" (γ) subunits.

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• Its main product is the heterotrimeric G-protein alpha subunit Gs-α, a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways.
• Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.
• The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
• The binding of this pheromone then leads to the activation of a heterotrimeric G protein.
• It is a mosaic disease arising from somatic activating mutations in "GNAS", which encodes the alpha-subunit of the Gs heterotrimeric G protein.

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• When a ligand binds to a G protein-coupled receptor (GPCR) that is coupled to a Gq heterotrimeric G protein, the α-subunit of Gq can bind to and induce activity in the PLC isozyme PLC-β, which results in the cleavage of PIP2 into IP3 and DAG.
• It is a type of heterotrimeric G-protein with different α subunits in rod and cone photoreceptors.
• Specific heterotrimeric G-protein type regulation is tissue-dependent for VMAT2; it is not known whether this is the case for VMAT1.