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- Similarly, genetically modifying mice to not express IL-23 or IL-17 receptors significantly reduced psoriatic lesion development upon stimulation with the lesion-causing tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
- Anti-miR-712 also inhibits vascular hyperpermeability, thereby significantly reducing atherosclerosis lesion development and immune cell infiltration.
- All stages of lesion development may be observed synchronously.
- The presence of HspB5 in biopsies can be a marker for lesion development.
- The optimum temperature for the disease development has been reported to be 15-20 °C, the first symptom seen after 6 hours of leaf wetness, with the lesion development decreasing with increasing periods of dryness.
- It consequently inhibited choline-enhanced endogenous macrophage foam cell formation and atherosclerotic lesion development in mice without alterations in circulating cholesterol levels.
- Dogs with active lesion development and / or widespread disease may be treated with pentoxyfylline, a drug that is useful in small vessel vasculitis, or tacrolimus, an ointment that will help suppress the inflammation in the affected areas.
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