Übersetzung für 'nAChRs' von Englisch nach Deutsch
nicotinic acetylcholine receptors <nAChRs>
Nikotinacetylcholinrezeptoren {pl} <nAChR>
1 Übersetzung
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Übersetzung für 'nAChRs' von Englisch nach Deutsch

nicotinic acetylcholine receptors <nAChRs>
Nikotinacetylcholinrezeptoren {pl} <nAChR>biochem.
Anwendungsbeispiele Englisch
  • Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice.
  • It causes a postsynaptic block at the NMJ nAChRs by preventing the binding of acetylcholine to its receptor.
  • α4β2 nAChRs contain two α4 subunits and three β2 subunits, therefore it has two binding sites for ACh and other agonists.
  • Nicotinic acetylcholine receptor (nAChRs) are present in the VB.
  • Anatoxin-a binding to these nAchRs cause the same effects in neurons.

  • Other neonicotinoids have a negatively charged nitro or cyano group, which interacts with a unique, positively charged amino acid residue present on insect, but not mammalian nAChRs.
  • Low doses of epibatidine will only affect the nAChRs, due to a higher affinity to nAChRs than to mAChRs. Higher doses, however, will cause epibatidine to bind to the mAChRs.
  • Galantamine is a potent allosteric potentiating ligand of human nicotinic acetylcholine receptors (nAChRs) α4β2, α3β4, and α6β4, and chicken/mouse nAChRs α7/5-HT3 in certain areas of the brain.
  • A few studies indicate that the affinity for cotinine to the nicotinic acetylcholine receptors (nAChRs) is about 100 times lower than nicotine's.
  • Many of the most well-characterized 3FTx proteins exert their toxic effects through binding to nicotinic acetylcholine receptors (nAChRs), a family of ligand-gated ion channels.

  • Pinnatoxin A, G, E and F display a high-affinity antagonism for the neuronal α7 and muscle α12βϒδ nicotine acetylcholine receptors (nAChRs).
  • (+)-Catharanthine competitively inhibits α9α10 nAChRs with potencies higher than that at α3β4 and α4β2 nAChRs and directly blocks CaV2.2.
  • Nornicotine possess high affinity for alpha-6 and alpha-7 subunits of nAChRs. It also inhibits DAT in striatum via nAChR and releases dopamine in rats.
  • •Depolarizing NMBDs: produces skeletal muscle relaxation by binding directly with nAChRs to cause prolonged depolarization.
  • Neonicotinoids act as agonists for nAChR and are selectively toxic to insects versus mammals, because of a higher potency on insect than mammalian nAChRs.

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