| NOUN | an opioid agonist | opioid agonists |
NOUN article.ind sg | pl
21 Übersetzungen
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Anwendungsbeispiele Englisch
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- Levophenacylmorphan is a morphinan derivative that acts as an opioid agonist.
- Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.
- 6-Methylenedihydrodesoxymorphine is a potent μ-opioid agonist, 80x stronger than morphine.
- Enadoline is a drug which acts as a highly selective κ-opioid agonist.
- In contrast both the peptide delta agonist Deltorphin II and the non-peptide delta agonist (+)-BW373U86 actually stimulated respiratory function and blocked the respiratory depressant effect of the potent μ-opioid agonist alfentanil, without affecting pain relief.
- Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine.
- Thebacon is an opioid agonist narcotic analgesic of the middle range and a strong antitussive, primarily used in Europe, although it is no longer in common use.
- The substitution of certain bulky groups on nitrogen 17 converts an opioid agonist into an opioid antagonist, the most important of which is naloxone, a non-selective opioid antagonist with no opioid agonist properties whatsoever ("silent" antagonist).
- MC5 is a mu-opioid agonist but not delta-opioid agonist, with EC50 at the mu-opioid receptor of 0.545 μM (vs 0.194 μM for tianeptine).
- The authors point out that the nalbuphine moiety is approximately ten times more pharmacologically potent than the mixed opioid agonist/antagonist butorphanol on an "antagonist index" scale which quantitates the drug's ability to act both as an analgesic (via opioid KOR agonism) as well as a MOR antagonist.
- Several opioids, particularly levorphanol, methadone and ketobemidone, possess NMDA receptor antagonism in addition to their µ-opioid agonist properties.
- Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid agonist used for chronic pain and also for opioid dependence.
- Opioid agonist therapy (OAT) is the medical procedure of using a harm-reducing opioid that produces significantly less euphoria, such as methadone or buprenorphine to reduce opioid cravings in people who use illegal opioid, such as heroin; buprenorphine and methadone are taken under medical supervision.
- amphetamine is often dispensed as racemic salts while the more active dextroamphetamine is reserved for refractory cases or more severe indications; another example is methadone, of which one isomer has activity as an opioid agonist and the other as an NMDA antagonist.
- Dextromethorphan (the stereoisomer of levomethorphan, a semi-synthetic opioid agonist) and its metabolite dextrorphan have no opioid analgesic effect at all despite their structural similarity to other opioids; instead they are potent NMDA antagonists and sigma 1 and 2-receptor agonists and are used in many over-the-counter cough suppressants.
- δ-opioid agonists can produce respiratory depression at very high doses, at lower doses they have the opposite effect.
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