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 Übersetzung für 'proteasome' von Englisch nach Deutsch
NOUN   proteasome | proteasomes
biochem.biol.
proteasome
Proteasom {n}
pharm.
proteasome inhibitor
Proteasomhemmer {m}
pharm.
proteasome inhibitor
Proteasom-Hemmer {m}
biochem.biol.
ubiquitin proteasome system <UPS>
Ubiquitin-Proteasom-System {n} <UPS>
4 Übersetzungen
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Anwendungsbeispiele Englisch
  • The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.
  • The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.
  • Proteasome subunit beta type-6 also known as 20S proteasome subunit beta-1 (based on systematic nomenclature) is a protein that in humans is encoded by the "PSMB6" gene.
  • Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the "PSMB7" gene.
  • Proteasome subunit beta type-5 as known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the "PSMB5" gene.

  • Proteasome subunit alpha type-7 also known as 20S proteasome subunit alpha-4 is a protein that in humans is encoded by the "PSMA7" gene.
  • Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the "PSMB8" gene.
  • The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.
  • The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.
  • Proteasome subunit alpha type-4 also known as macropain subunit C9, proteasome component C9, and 20S proteasome subunit alpha-3 is a protein that in humans is encoded by the "PSMA4" gene.

  • The ubiquitin-proteasome system (UPS) figures prominently in protein degradation. The 26S proteasome consists of a catalytic subunit (the 20S core particle), and a regulatory subunit (the 19S cap).
  • In 1995, Schreiber and co-workers found that the small molecule lactacystin binds and inhibits specific catalytic subunits of the proteasome, a protein complex responsible for the bulk of proteolysis in the cell, as well as proteolytic activation of certain protein substrates.
  • Proteasome: The Deshaies group pioneered the use of affinity purification to rapidly purify and characterize the composition of eukaryotic proteasomes, leading to the discovery of a large number of factors, including Rpn13 and Ubp6, that interact with the proteasome in yeast cells.
  • Proteasome accessory factor E (abbreviated PafE, also known as bacterial proteasome activator or Bpa) is an ATP-independent proteasome activator of Mycobacterium tuberculosis that forms 12-fold symmetric rings and interacts with the 20S proteasome core particle through a conserved carboxyl-terminal motif to activate peptide and protein degradation.
  • Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the "PSMA8" gene.

  • Matouschek currently studies the proteasome, the degradation machinery of eukaryotic cells, and the mechanisms by which the proteasome is able to unfold and translocate proteins.
  • MG132 is a potent, reversible, and cell-permeable proteasome inhibitor These are substrate analogues and potent transition-state inhibitors of chymotrypsin like activity of proteasome machinery.
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