Übersetzung für 'ubiquitylation' von Englisch nach Deutsch

ubiquitylation

Ubiquitylierung {f}biochem.

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ubiquitylation machinery

Ubiquitinierungs­maschinerie {f}biochem.

• It was found that certain CCNF mutations caused increased ubiquitylation activity of cyclin F leading to abnormal ubiquitylation of proteins.
• The addition of ubiquitin (ubiquitylation) marks a protein for degradation via the proteasome.
• ITCH serves as a paradigm for our understanding of the regulation of the ubiquitylation machinery by direct protein phosphorylation of its components.
• Since the ubiquitylation system is shared across all organisms, studies can use modified E2 proteins in order to understand the overall system for how all organisms process proteins.
• protein hydroxylates the proline at the 564 position of HIF-1 alpha, which allows ubiquitylation by the von Hippel-Lindau tumor suppressor (pVHL) and subsequent targeting for proteasome degradation.

• While Hsc70 also performed chaperone functions under normal conditions, unlike canonical heat shock proteins, Hsc70 is constitutively expressed and performs functions related to normal cellular processes, such as protein ubiquitylation and degradation.
• An autoinflammatory condition identified in 2020 and named VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is due to mutation in methionine41 in UBA1, the E1 enzyme that initiates ubiquitylation.
• As a postdoctoral researcher, Beat Fierz contributed to the understanding that chromatin ubiquitylation opens chromatin structure, increasing local chromatin accessibility.
• There are diverse modifications at H3K36, such as phosphorylation, methylation, acetylation, and ubiquitylation, which have many important biological processes.
• Shown on the structure are the two known phosphorylated sites and one ubiquitylation site.

• The ubiquitylation system was initially characterised as an ATP-dependent proteolytic system present in cellular extracts.
• In 2016 she was elected to the National Academy of Sciences. Her recent research concerns protein energetics, folding and turnover as altered by protein ubiquitylation.
• Many APC substrates contain both D and KEN boxes, with their ubiquitylation by either APC/CCdc20 or APC/CCdh1 dependent on both sequences, yet some substrates contain only either a D box or a KEN box, in one or multiple copies.
• Because Cdk1-Clb2 inhibits Sic1 by phosphorylating Sic1 and making Sic1 available for degradation via ubiquitylation, APC-Cdh1-dependent degradation of Cdk1-Clb2 not only decreases the level of available Cdk1-Clb2 complexes but also increases the level of Sic1 which in turn further inhibits the function of Cdk1-Clb2.
• The focus of the DSTT is the study of protein phosphorylation and ubiquitylation.

• Recently TKIs have been shown to deprive tyrosine kinases of access to the Cdc37-Hsp90 molecular chaperone system on which they depend for their cellular stability, leading to their ubiquitylation and degradation.
• His other research interests include lipid signaling (especially a group of lipids known as phosphatidylinositol phosphates), protein transport in cells by vesicles and the role of arrestin and ubiquitylation in the degradation of membrane proteins.
• The ubiquitylation of mitochondrial surface proteins brings in mitophagy initiating factors.