Übersetzung für 'zalcitabine' von Englisch nach Deutsch

zalcitabine <ZCB>

Zalcitabin {n} <ZCB>pharm.

• Horwitz was also first to synthesize stavudine (d4T) and zalcitabine (ddC) - two other reverse-transcriptase inhibitors used in the treatment of HIV patients.
• Lamividine/zidovudine interacts with stavudine and zalcitabine by competing intracellularly for activation and results in inhibiting phosphorylation.
• For instance, oxidation with peroxy acids such as peroxyacetic acid produces optically pure 5-hydroxymethyldihydrofuranone, from which zalcitabine, formerly a HIV drug, is available.
• The sale and distribution of zalcitabine has been discontinued since December 31, 2006.
• NRTIs approved by the FDA are zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine and the only nucleotide reverse-transcriptase inhibitor (NtRTI) approved is tenofovir (see table 4).

• The most common mutation observed "in vivo" is L74V in the viral "pol" gene, which confers cross-resistance to zalcitabine; other mutations observed include K65R and M184V .