Translation for 'neurodegeneration' from English to French

neurodegeneration

neurodégénérescence {f}méd.

• The pseudopupil analysis technique is used to study neurodegeneration in insects like "Drosophila."
• De novo loss of function mutations in "WDR45" were identified by exome sequencing in 20 patients with progressive neurodegeneration and evidence of iron on brain MRI scans.
• Long-term exposure to cypermethrin during adulthood is found to induce dopaminergic neurodegeneration in rats, and postnatal exposure enhances the susceptibility of animals to dopaminergic neurodegeneration if rechallenged during adulthood.
• A Purkinje cell specific knock out of the Mecr gene in mice leads to neurodegeneration.
• Mutations in "PLA2G6" has been shown to result in mitochondrial deficiencies and associated disorders, including PLA2G6-associated neurodegeneration (PLAN), which has several subtypes and is also known as Neurodegeneration with brain iron accumulation type 2 (NBIA2), other forms of disease are also referred to as Parkinson disease 14 (PARK14), and hereditary spastic paraplegia.

• Yasuda H (1999). Prevention of neurodegeneration by a neuroprotective radical scavenger.
• Molecular genetic studies revealed a homozygous mutation in the C19ORF12 gene which has been previously reported in patients with mitochondrial membrane protein-associated neurodegeneration (MPAN) a variant of neurodegeneration with brain iron accumulation (NBIA).
• Neuromelanin has been shown to bind neurotoxic and toxic metals that could promote neurodegeneration.
• Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a genetic neurodegenerative disease that causes dystonia, parkinsonism, and iron accumulation in the brain.
• Quintana's research investigates signaling pathways that control the immune response and neurodegeneration, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders.

• It seems that Fas and MIF are candidate biomarkers of progressive neurodegeneration.
• In 2017 FDA granted RT001 orphan drug designation in the treatment of phospholipase 2G6-associated neurodegeneration (PLAN).
• Her lab is interested in understanding mechanisms of neurodegeneration.
• Evidence of neurodegeneration can be supported by an increased microglia density and expression of proinflammatory cytokines in the brain.
• "Molecular Neurodegeneration" is a peer-reviewed scientific journal covering research on the molecular mechanisms underlying neurodegeneration, especially as pertaining to neurodegenerative diseases.

• Other projects Ackerman has been involved in include the mutation of a U2 snRNA and its connection to neurodegeneration, an editing defective tRNA synthetase that leads to protein misfolding and neurodegeneration, and ribosome stalling by tRNA mutations that leads to neurodegeneration.
• The final main focus of her research is on neurodegeneration, as part of a 4-lab collaboration with the groups of Aimee Kao, Matt Jacobson, and Torsten Wittman.
• In 2017, FDA granted RT001 orphan drug designation in the treatment of phospholipase 2G6-associated neurodegeneration (PLAN).
• Peptide T clinical development was stopped due to the propensity of the liquid nasal spray to lose potency upon storage and shifted to its shorter oral analog, the pentapeptide CCR2/CCR5 antagonist RAP-103 (Receptor Active Peptide) for neuropathic pain and neurodegeneration.
• Elderly people often experience multiple comorbidities that may contribute to the phenomenon of sundowning syndrome through neurodegeneration.