Translation for 'topoisomerase' from English to Russian
NOUN   topoisomerase | topoisomerases
топоизомераза {ж}
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Translation for 'topoisomerase' from English to Russian

топоизомераза {ж}биол.
Usage Examples English
  • Amrubicin acts by inhibiting topoisomerase II, and has been compared in clinical trials with topotecan, a Topoisomerase I inhibitor.
  • DNA topoisomerase 1 is an enzyme that in humans is encoded by the "TOP1" gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.
  • Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma.
  • ... 2) that inhibits the bacterial topoisomerase I. Gp55.2 binds DNA and specifically blocks the relaxation of negatively supercoiled DNA by topoisomerase I.
  • Topoisomerase inhibitors are chemical compounds that block the action of topoisomerases, which are broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII).

  • Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II.
  • Cinoxacin mode of action involves the inhibiting of DNA gyrase, a type II topoisomerase, and topoisomerase iv, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division.
  • It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate, replicated DNA, thereby inhibiting cell division.
  • It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell replication.
  • For semiconservative replication to occur, the DNA double-helix needs to be separated so the new template strand can be bound to the complementary base pairs. Topoisomerase is the enzyme that aids in the unzipping and recombination of the double-helix.

  • This is by far the most-accepted mechanism to explain the action of anthracyclines as topoisomerase-II mediated toxicity is evident at clinically relevant drug concentrations.
  • It is suspected that the helicase and topoisomerase domains of the reverse gyrase enzyme work together to promote positive supercoiling in DNA.
  • Topoisomerase is a lucrative target for cancer therapy due to its critical role as an enzyme in DNA replication, and many topoisomerase inhibitors have been made.
  • She is the author of the hypothesis linking etiology of systemic sclerosis to a mutation in the topoisomerase I gene and abnormal topoisomerase I expression.
  • Caroline's published research focuses on human DNA topoisomerase II and anti-cancer agents that target these enzymes; a particular recent interest is investigating secondary, therapy-related leukemias associated with topoisomerase II.

  • We often forget that DNA gyrase does in fact have topoisomerase type II activity; thus, with it being a homologue of topoisomerase IV (also having topoisomerase II activity) we expect similarity in the two proteins' functions.
  • Belotecan blocks topoisomerase I with a pIC50 of 6.56, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis.
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Contains translations by TU Chemnitz and Mr Honey's Business Dictionary (German-English only).
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